WELCOME

A real-time interactive software tool for individualized dosing of monoclonal antibodies in Pediatric care.

This dosing application utilizes a previously established Physiological-based Pharmacokinetic (PBPK) model to predict the PK of monoclonal antibodies in children across age, weight, gender and dosing regimen.

  WHAT YOU CAN DO WITH THIS DOSING TOOL:

• Without the need for previous concentration information, perform Population Simulation.
• Predict a pediatric patient's PK based on age, weight, gender, and previous concentration information, supporting subsequent individualized dosing decisions.
• Individualised Dosing and Population Simulation is available for Intravenously administered Avelumab, Atezolizumab, Bevacizumab, Basiliximab, Dinutuximab,Palivizumab, Ustekinumab, Tocilizumab and Population Simulation is available for Sub Cutaneously administered Adalimumab, Canakinumab, Dupilumab, Mepolizumab.

TO GET STARTED:

Choose your drug

Does your patient have previous concentration information?

For more information about the PBPK model:

https://pubmed.ncbi.nlm.nih.gov/34189743/

This effort is also part of the MPRINT project

For more information:

https://mprint.org/index.html